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Squamous cell carcinomas in the anal canal have grown beyond the surface and into the deeper layers of the lining (as opposed to carcinoma in situ which is only in the surface cells). Cloacogenic carcinomas (also called basaloid or transitional cell carcinomas ) are a type of squamous cell cancer. Progression of anal cancer (squamous cell carcinoma of the anus) anal cancer spreads by local invasion initially, and then via the lymphatics with inguinal, pelvic, para-aortic and iliac nodes being the most common sites of early anal cancer spread. Anal cancer is a cancer which arises from the anus, the distal opening of the gastrointestinal tract. Symptoms may include bleeding from the anus or a lump near the anus. Other symptoms may include pain, itchiness, or discharge from the anus. Anal carcinoma and 80 of anal cancers are squamous cell carcinomas (sccs). Other tumour types include melanoma , lymphoma and adenocarcinoma. Squamous cell carcinomas (sccs), also known as epidermoid carcinomas, comprise a number of different types of cancer that result from squamous cells. These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts. anal squamous cell carcinoma is thought to arise from a precursor lesion termed anal intraepithelial neoplasia (ain) (figure (figure3). Ain is a histologic, as opposed to cytologic, diagnosis with varying degrees of dysplasia. Squamous cell anal carcinoma occurs when the skin cells spread beyond the surface to the deeper layers of the lining in or on the anus and grow uncontrollably. 0 evaluations from squamous cell anal cancer patients report slight effectiveness of fluorouracil for squamous cell.