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Tacrolimus ointment, a potent immunosuppressive medication, was evaluated for efficacy in the treatment of perianal fistulas in dogs. Ten dogs with perianal fistulas were treated with topical tacrolimus ointment once to twice daily for 16 weeks. Full healing of the fistulas occurred in 50 and was noticeably improved in 90 of dogs. If youve ever had an abscess, you know the pain of that pus-filled swelling. An anal fistula in a dog consists of an abscess in the perianal region, accompanied by fissures that repeatedly drain. In most cases, your vet will start with medical management and proceed. Perianal fistula, also known as anal furunculosis is a serious medical condition that most commonly affects german shepherd dogs. Perianal fistulas are characterized by chronic, purulent, smelly, ulcerating, sinus tracts in the anal region and surrounding skin. More recent studies indicate that the condition is more likely caused by an autoimmune disease. Following is some general information concerning perianal fistulas in dogs, what they are and how affect dogs along with some details about a perianal fistula dog diet. Perianal fistulas in dogs also known as anal furunculosis , or perianal sinus , perianal fistula is a medical condition that may affect a variety of dogs, but certain breeds are particularly predisposed. Perianal fistulas are tunnel-like formations in the skin and deeper tissues that surround the anal area of dogs. The lesions vary in severity but at first appear as small oozing holes in the skin. These holes may become wide and deep and surround the entire circumference of the anus. Tacrolimus for the treatment of fistulas in patients with crohns disease a randomized, placebo-controlled trial william j. Feagan, lloyd mayer, therese johnson, joseph galanko, christopher martin, and robert s. Anal furunculosis is a chronic progressive canine inflammatory disorder affecting the anus and the perianal region, resulting in ulcers and blind fistula in the skin and subcutaneous tissues of.